The synaptic connection

It is easy to understand how important the formation of correct synaptic connections is during neural circuitry formation. The Teneurin family of proteins promotes these connections between cells playing an essential role in neuron-neuron adhesion.

At the Kavli Institute of Nanoscience (TUDelft) together with the Utrecht University have resolved the dimeric ectodomain of human Teneurin4 structure with 2.7 Ă… resolution. In the world of proteins, structure is directly related to function. And this amazing research, which has been featured in the cover of EMBO Journal, supports the role for teneurins as a scaffold for macromolecular complex assembly and the establishment of cis- and trans-synaptic interactions to construct functional neuronal circuits.

We made this picture to illustrate the behaviour of Teneurin, closely advised by Dr. Dimphna Meijer.

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