Influenza: the secret of its success

We, as human’s, are pretty familiar with the influenza A virus, so it is confusing to know how much there is still to learn about it. And researchers from CSIC have just reduced our ignorance about it a little bit more. Together with researchers from Stockholm University, CNRS, and Institut Pasteur, and using cryoelectron microscopy, they’ve  unveiled the transcription mechanism of this virus. This is important, among other reasons, to understand why this virus is so successful. And its been published in Nature Microbiology.

The molecules responsible for transcription are the ribonucleoproteins (RNPs). This RNPs which are extremely flexible, adopt a double helical conformation. In this configuration, the RNA, attached to the RNPs, slides in a sort of worm drive fashion. This process can be seen in the video we made for them as supplementary information for their paper. As put by the researchers, “the flexibility of the viral RNPs is key and explains how the virus is able to create a big amount of proteins from a limited number of genes”.

We also attempted the cover of Nature with this picture.

I’ve never whined about not getting a cover, but there is always a first. I’ve had the privilege to follow this research for about two years, thanks to Jaime MartĂ­n-Benito, so I can’t but feel it as something personal. The discovery is amazingly important and the picture is really beautiful (idea of Jaime MartĂ­n-Benito, corresponding author of the paper). And it deserves to be shown! So here it is for your enjoyment.

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